Theoretical study of the separation mechanism of ionizable compounds in capillary electrochromatography

被引：15

作者：

Ye, ML ^{[1
]}

Zou, HF ^{[1
]}

Liu, Z ^{[1
]}

Zhu, J ^{[1
]}

Ni, JY ^{[1
]}

Zhang, YK ^{[1
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116011, Peoples R China

来源：

SCIENCE IN CHINA SERIES B-CHEMISTRY | 1999年 / 42卷 / 06期

基金：

中国国家自然科学基金;

关键词：

capillary electrochromatography; pressurized capillary electrochromatography; ionizable compounds; separation mechanism;

D O I：

10.1007/BF02874330

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The migration mechanism of ionizable compounds in capillary electrochromatography (CEC) is more complicated than in high performance liquid chromatography (HPLC) due to the involvement of electrophoresis and the second chemical equilibrium. The separation mechanism of ionizable compounds in CEC has been studied theoretically. The electrochromatographic capacity factors of ions (k *) in CEC and in the pressurized CEC are derived by phenomenological approach. The influence of pH, voltage, pressure on k* is discussed. in addition, the k * of weak acid and weak base are derived based on acid-base equilibrium and the influence of pH on k * is studied theoretically.

引用

页码：639 / 648

页数：10

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