Modeling cell signaling networks

被引：87

作者：

Eungdamrong, NJ ^{[1
]}

Iyengar, R ^{[1
]}

机构：

[1] CUNY Mt Sinai Sch Med, Dept Pharmacol & Biol Chem, New York, NY 10029 USA

来源：

BIOLOGY OF THE CELL | 2004年 / 96卷 / 05期

关键词：

G protein pathways; signaling networks; models; computational analysis;

D O I：

10.1016/j.biolcel.2004.03.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cell signaling pathways interact with one another to form networks in mammalian systems. Such networks are complex in their organization and exhibit emergent properties such as bistability and ultrasensitivity. Analysis of signaling networks requires a combination of experimental and theoretical approaches including the development and analysis of models. This review focuses oil theoretical approaches to understanding cell signaling networks. Using heterotrimeric G protein pathways an example, we demonstrate how interactions between two pathways can result in a network that contains a positive feedback loop and function as a switch. Different mathematical approaches that are currently used to model signaling networks are described, and future challenges including the need for databases as well as enhanced computing environments are discussed. (C) 2004 Elsevier SAS. All rights reserved.

引用

页码：355 / 362

页数：8