A novel strategy toward [6,5]-bicyclic β-turn dipeptide

被引：33

作者：

Gu, XY

Tang, XJ

Cowell, S

Ying, JF

Hruby, VJ

机构：

[1] Univ Arizona, Dept Chem, Tucson, AZ 85721 USA

[2] CB Res & Dev Inc, New Castle, DE 19720 USA

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 37期

基金：

美国国家科学基金会;

关键词：

beta-turn mimetic; bicyclic turned dipeptide; Ni(II)-complexes; delta; epsilon-unsaturated amino acids;

D O I：

10.1016/S0040-4039(02)01338-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel strategy toward the syntheses of [6,5]-bicyclic beta-turn dipeptides has been developed starting from delta,epsilon-unsaturated amino acids. This is the first example showing that this scaffold can be synthesized front a terminal alkene using a trifluoroacetyl protected amino acid. Both enantiomers of the delta,epsilon-unsaturated amino acid were synthesized by a modified method using Ni(II)-complexes. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：6669 / 6672

页数：4

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