Seeking a function for spontaneous neurotransmission

被引:14
作者
Chung, ChiHye [1 ]
Kavalali, Ege T.
机构
[1] Univ Texas, SW Med Ctr, Ctr Basic Neurosci, Dallas, TX 75390 USA
[2] Univ Texas, SW Med Ctr, Dept Physiol, Dallas, TX 75390 USA
关键词
D O I
10.1038/nn0806-989
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
A recent study proposes that the random and spontaneous, NMDA receptor-dependent miniature postsynaptic currents at hippocampal synapses serve to regulate local postsynaptic protein synthesis, thereby stabilizing synaptic function.
引用
收藏
页码:989 / 990
页数:2
相关论文
共 15 条
[1]   A STUDY OF SUPERSENSITIVITY IN DENERVATED MAMMALIAN SKELETAL MUSCLE [J].
AXELSSON, J ;
THESLEFF, S .
JOURNAL OF PHYSIOLOGY-LONDON, 1959, 147 (01) :178-193
[2]   Neuronal activity regulates diffusion across the neck of dendritic spines [J].
Bloodgood, BL ;
Sabatini, BL .
SCIENCE, 2005, 310 (5749) :866-869
[3]  
Cannon WB, 1949, SUPERSENSITIVITY DEN
[4]  
FATT P, 1952, J PHYSIOL-LONDON, V117, P109
[5]   CA2+ PERMEABILITY OF KA-AMPA GATED GLUTAMATE RECEPTOR CHANNELS DEPENDS ON SUBUNIT COMPOSITION [J].
HOLLMANN, M ;
HARTLEY, M ;
HEINEMANN, S .
SCIENCE, 1991, 252 (5007) :851-853
[6]   Activity-dependent modulation of synaptic AMPA receptor accumulation [J].
O'Brien, RJ ;
Kamboj, S ;
Ehlers, MD ;
Rosen, KR ;
Fischbach, GD ;
Huganir, RL .
NEURON, 1998, 21 (05) :1067-1078
[7]   Transient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiation [J].
Plant, K ;
Pelkey, KA ;
Bortolotto, ZA ;
Morita, D ;
Terashima, A ;
McBain, CJ ;
Collingridge, GL ;
Isaac, JTR .
NATURE NEUROSCIENCE, 2006, 9 (05) :602-604
[8]   An isolated pool of vesicles recycles at rest and drives spontaneous neurotransmission [J].
Sara, Y ;
Virmani, T ;
Deák, F ;
Liu, XR ;
Kavalali, ET .
NEURON, 2005, 45 (04) :563-573
[9]   Regulation of dendritic protein synthesis by miniature synaptic events [J].
Sutton, MA ;
Wall, NR ;
Aakalu, GN ;
Schuman, EM .
SCIENCE, 2004, 304 (5679) :1979-1983
[10]   Miniature neurotransmission stabilizes synaptic function via tonic suppression of local dendritic protein synthesis [J].
Sutton, Michael A. ;
Ito, Hiroshi T. ;
Cressy, Paola ;
Kempf, Christian ;
Woo, Jessica C. ;
Schuman, Erin M. .
CELL, 2006, 125 (04) :785-799