Projection OCT fundus imaging for visualising outer retinal pathology in non-exudative age-related macular degeneration

被引：46

作者：

Gorczynska, I. ^{[1
,2
,3
]}

Srinivasan, V. J. ^{[1
,2
]}

Vuong, L. N. ^{[3
]}

Chen, R. W. S. ^{[3
]}

Liu, J. J. ^{[1
,2
]}

Reichel, E. ^{[3
]}

Wojtkowski, M. ^{[4
]}

Schuman, J. S. ^{[5
]}

Duker, J. S. ^{[3
]}

Fujimoto, J. G. ^{[1
,2
]}

机构：

[1] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA

[2] MIT, Elect Res Lab, Cambridge, MA 02139 USA

[3] Tufts Univ, New England Eye Ctr, Tufts Med Ctr, Boston, MA 02111 USA

[4] Nicholas Copernicus Univ, Inst Phys, PL-87100 Torun, Poland

[5] Univ Pittsburgh, Sch Med, Dept Ophthalmol, UPMC Eye Ctr, Pittsburgh, PA 15261 USA

来源：

BRITISH JOURNAL OF OPHTHALMOLOGY | 2009年 / 93卷 / 05期

基金：

美国国家科学基金会;

关键词：

OPTICAL COHERENCE TOMOGRAPHY; HIGH-SPEED; THICKNESS;

D O I：

10.1136/bjo.2007.136101

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Aims: To demonstrate ultrahigh-resolution, three-dimensional optical coherence tomography (3D-OCT) and projection OCT fundus imaging for enhanced visualisation of outer retinal pathology in non-exudative age-related macular degeneration (AMD). Methods: A high-speed, 3.5 mu m resolution OCT prototype instrument was developed for the ophthalmic clinic. Eighty-three patients with non-exudative AMD were imaged. Projection OCT fundus images were generated from 3D-OCT data by selectively summing different retinal depth levels. Results were compared with standard ophthalmic examination, including fundus photography and fluorescein angiography, when indicated. Results: Projection OCT fundus imaging enhanced the visualisation of outer retinal pathology in non-exudative AMD. Different types of drusen exhibited distinct features in projection OCT images. Photoreceptor disruption was indicated by loss of the photoreceptor inner/outer segment (IS/OS) boundary and external limiting membrane (ELM). RPE atrophy can be assessed using choroid-level projection OCT images. Conclusions: Projection OCT fundus imaging facilities rapid interpretation of large 3D-OCT data sets. Projection OCT enhances contrast and visualises outer retinal pathology not visible with standard fundus imaging or OCT fundus imaging. Projection OCT fundus images enable registration with standard ophthalmic diagnostics and cross-sectional OCT images. Outer retinal alterations can be assessed and drusen morphology, photoreceptor impairment and pigmentary abnormalities identified.

引用

页码：603 / 609

页数：7

共 25 条

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