Relaxed Selection Limits Lifespan by Increasing Mutation Load

被引：89

作者：

Cui, Rongfeng ^{[1
]}

Medeiros, Tania ^{[1
]}

Willemsen, David ^{[1
]}

Iasi, Leonardo N. M. ^{[1
]}

Collier, Glen E. ^{[2
]}

Graef, Martin ^{[1
,4
]}

Reichard, Martin ^{[3
]}

Valenzano, Dario Riccardo ^{[1
,4
]}

机构：

[1] Max Planck Inst Biol Ageing, D-50931 Cologne, Germany

[2] Univ Tulsa, Dept Biol Sci, Tulsa, OK 74104 USA

[3] Czech Acad Sci, Inst Vertebrate Biol, Brno 60365, Czech Republic

[4] Univ Cologne, CECAD, D-50931 Cologne, Germany

来源：

CELL | 2019年 / 178卷 / 02期

关键词：

DNA-POLYMERASE GAMMA; MULTIPLE SEQUENCE ALIGNMENT; EVOLUTIONARY ADAPTATION; PHYLOGENETIC ANALYSIS; POPULATION HISTORY; PROVIDES INSIGHTS; READ ALIGNMENT; GENOME; PROTEIN; TOOL;

D O I：

10.1016/j.cell.2019.06.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

To uncover the selective forces shaping life-history trait evolution across species, we investigate the genomic basis underlying adaptations to seasonal habitat desiccation in African killifishes, identifying the genetic variants associated with positive and relaxed purifying selection in 45 killifish species and 231 wild individuals distributed throughout sub-Saharan Africa. In annual species, genetic drift led to the expansion of nuclear and mitochondrial genomes and caused the accumulation of deleterious genetic variants in key life-history modulating genes such as mtor, insr, ampk, foxo3, and polg. Relaxation of purifying selection is also significantly associated with mitochondrial function and aging in human populations. We find that relaxation of purifying selection prominently shapes genomes and is a prime candidate force molding the evolution of lifespan and the distribution of genetic variants associated with late-onset diseases in different species.

引用

页码：385 / +

页数：35

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