A deep, water-soluble cavitand acts as a phase-transfer catalyst for hydrophobic species

被引：58

作者：

Hooley, Richard J.

Biros, Shannon M.

Rebek, Julius, Jr.

机构：

[1] Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 21期

关键词：

aqueous reactions; hydrophobic effect; molecular recognition; NMR spectroscopy; phase-transfer catalysis;

D O I：

10.1002/anie.200600405

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Overcoming inhibition: A deep, water-soluble cavitand has been shown to extract various N-substituted maleimides into aqueous solution through the hydrophobic effect. These complexes react with a water-soluble thiol to confer water solubility to the product, thus leading to a drastic reduction in binding affinity and allowing this system to function as a phase-transfer catalyst. (Chemical Equation Presented). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：3517 / 3519

页数：3

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