Desmosomal cadherins

被引：181

作者：

Garrod, DR ^{[1
]}

Merritt, AJ ^{[1
]}

Nie, ZX ^{[1
]}

机构：

[1] Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England

来源：

CURRENT OPINION IN CELL BIOLOGY | 2002年 / 14卷 / 05期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0955-0674(02)00366-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

New evidence from blocking desmosomal adhesion with anti-adhesion peptides reveals a role for desmosomes in cell positioning in morphogenesis. Desmosomal adhesion is necessary for the stability of adherens junctions in epithelial cell sheets. Knockout and mis-expression of desmosomal cadherins in mice suggests that they may function directly or indirectly in regulating epidermal differentiation. Protein kinase C signalling and tyrosine phosphorylation appear to regulate desmosomal adhesion. There are new insights into the role of desmosomal cadherins in autoimmune, infectious and genetic disease.

引用

页码：537 / 545

页数：9

共 96 条

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