Thrombin and Brain Recovery After Intracerebral Hemorrhage

被引：31

作者：

Hua, Ya ^{[1
]}

Keep, Richard F. ^{[1
]}

Gu, Yuxiang ^{[1
]}

Xi, Guohua ^{[1
]}

机构：

[1] Univ Michigan, Dept Neurosurg, Ann Arbor, MI 48109 USA

来源：

STROKE | 2009年 / 40卷 / 03期

基金：

美国国家卫生研究院;

关键词：

angiogenesis; cerebral hemorrhage; neurogenesis; plasticity; thrombin; ENDOTHELIAL PROGENITOR CELLS; PROTEASE-ACTIVATED RECEPTOR-1; INJURY;

D O I：

10.1161/STROKEAHA.108.533281

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Intracerebral hemorrhage (ICH) is a common and often fatal subtype of stroke and produces severe neurological deficits in survivors. At present, there is lack of effective treatments that improve outcome in ICH. A neglected aspect of ICH research is the development of approaches that can be effectively used to improve recovery. Although previous studies have showed that thrombin induces blood-brain barrier leakage, brain edema, and neuronal death after ICH, our recent studies have shown that thrombin may have a role in brain recovery after ICH. An understanding of the mechanisms by which thrombin affects neurogenesis, angiogenesis, and plasticity may facilitate brain recovery after ICH. (Stroke. 2009; 40[suppl 1]: S88-S89.)

引用

收藏

页码：S88 / S89

页数：2

相关论文

共 14 条

[1] Learning and memory deficits in mice lacking protease activated receptor-1 [J].

Almonte, Antoine G. ;

Hamill, Cecily E. ;

Chhatwal, Jasmeer P. ;

Wingo, Thomas S. ;

Barber, Jeremy A. ;

Lyuboslavsky, Polina N. ;

Sweatt, J. David ;

Ressler, Kerry J. ;

White, David A. ;

Traynelis, Stephen F. .

NEUROBIOLOGY OF LEARNING AND MEMORY, 2007, 88 (03) :295-304

[2] Thrombin induces expression of FGF-2 via activation of PI3K-Akt-Fra-1 signaling axis leading to DNA synthesis and motility in vascular smooth muscle cells [J].

Cao, HQ ;

Dronadula, N ;

Rao, GN .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2006, 290 (01) :C172-C182

[3] Thrombin signalling and protease-activated receptors [J].

Coughlin, SR .

NATURE, 2000, 407 (6801) :258-264

[4] Thrombin preconditioning attenuates brain edema induced by erythrocytes and iron [J].

Hua, Y ;

Keep, RF ;

Hoff, JT ;

Xi, GH .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2003, 23 (12) :1448-1454

[5] Behavioral tests after intracerebral hemorrhage in the rat [J].

Hua, Y ;

Schallert, T ;

Keep, RF ;

Wu, JM ;

Hoff, JT ;

Xi, GH .

STROKE, 2002, 33 (10) :2478-2484

[6] Endothelial progenitor cells:: Characterization, in vitro expansion, and prospects for autologous cell therapy [J].

Smadja, D. M. ;

Cornet, A. ;

Emmerich, J. ;

Aiach, M. ;

Gaussem, P. .

CELL BIOLOGY AND TOXICOLOGY, 2007, 23 (04) :223-239

[7] The angiopoietin pathway is modulated by PAR-1 activation on human endothelial progenitor cells [J].

Smadja, D. M. ;

Laurendeau, I. ;

Avignon, C. ;

Vidaud, M. ;

Aiach, M. ;

Gaussem, P. .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2006, 4 (09) :2051-2058

[8] Thrombin and PAR-1 stimulate differentiation of bone marrow-derived endothelial progenitor cells [J].

Tarzami, ST ;

Wang, G ;

Li, W ;

Green, L ;

Singh, JP .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2006, 4 (03) :656-663

[9] Inhibition of angiogenesis by small-molecule antagonists of protease-activated receptor-1 [J].

Tsopanoglou, Nikos E. ;

Maragoudakis, Michaeg E. .

SEMINARS IN THROMBOSIS AND HEMOSTASIS, 2007, 33 (07) :680-687

[10] The role of thrombin-like (serine) proteases in the development, plasticity and pathology of the nervous system [J].

Turgeon, VL ;

Houenou, LJ .

BRAIN RESEARCH REVIEWS, 1997, 25 (01) :85-95