A multispecialty approach to the diagnosis and management of pancreatic cancer

被引:170
作者
Hawes, RH
Xiong, QH
Waxman, I
Chang, KJ
Evans, DB
Abbruzzese, JL
机构
[1] Univ Texas, MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77303 USA
[2] Univ Texas, MD Anderson Canc Ctr, Dept Gastrointestinal Med Oncol & Digest Dis, Houston, TX 77303 USA
[3] Med Univ S Carolina, Charleston, SC 29425 USA
[4] Univ Texas, Div Gastroenterol, Med Branch, Galveston, TX 77550 USA
[5] Univ Calif Irvine, Orange, CA 92668 USA
关键词
D O I
10.1111/j.1572-0241.2000.01699.x
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
This article reviews recent developments in pancreatic cancer research and offers a multispecialty perspective on the diagnosis and management of this challenging disease. Current findings in the molecular biology of the disease and their implications for management are examined, as well as development in diagnostic techniques, including helical computed tomography (CT), magnetic resonance imaging (MRI), magnetic resonance cholangio-pancreatography (MRCP), and, particularly, endoscopic ultrasound-guided fine-needle aspiration. Surgical management, the role of adjuvant/neoadjuvant chemoradiation therapy, and the critical importance of accurate preoperative imaging are also addressed in this review. Palliative techniques, including endoscopic stenting for malignant obstructive jaundice and chemotherapy for locally advanced and metastatic disease, are discussed, and results of recent clinical trials in pancreatic cancer are summarized. Finally, future directions for research are identified.
引用
收藏
页码:17 / 31
页数:15
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