Therapeutic Noninvasive Brain Stimulation in Alzheimer's Disease

被引：62

作者：

Gonsalvez, Irene ^{[1
,2
]}

Baror, Roey ^{[1
,3
]}

Fried, Peter ^{[1
]}

Santarnecchi, Emiliano ^{[1
,4
]}

Pascual-Leone, Alvaro ^{[1
]}

机构：

[1] Harvard Med Sch, Div Cognit Neurol, Dept Neurol, Berenson Allen Ctr Noninvas Brain Stimulat,Beth I, Boston, MA USA

[2] St Elisabeths Med Ctr, Dept Psychiat, Brighton, MA USA

[3] Univ Cambridge, Dept Clin Neurosci, MRC Cambridge Stem Cell Inst, Welcome Trust, Cambridge, England

[4] Univ Siena, Brain Investigat & Neuromodulat Lab, I-53100 Siena, Italy

来源：

CURRENT ALZHEIMER RESEARCH | 2017年 / 14卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Alzheimer's disease; transcranial magnetic stimulation; TMS; tDCS; dementia; noninvasive brain stimulation; NBS; TRANSCRANIAL MAGNETIC STIMULATION; ELECTRICAL NERVE-STIMULATION; HUMAN MOTOR CORTEX; APOLIPOPROTEIN-E; CORTICAL EXCITABILITY; NEUROTROPHIC FACTOR; MAJOR DEPRESSION; HYPOTHETICAL MODEL; AFFECTIVE BEHAVIOR; COGNITIVE FUNCTION;

D O I：

10.2174/1567205013666160930113907

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Alzheimer's disease (AD) is a looming public health crisis that currently lacks an effective treatment. Noninvasive Brain Stimulation (NBS), particularly transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS), offers a promising alternative approach to pharmacological interventions for an increasing number of neurological and psychiatric conditions. The aim of this review is summarize data from therapeutic trials of NBS in AD and other dementing illnesses. Despite the potential of NBS, there is limited theoretical framework and a lack of guidelines for its applications to AD. Several published clinical trials failed to report key parameters of the interventions thus limiting the utility of the study to assess efficacy and safety. Our review concludes with some suggestions for future studies aimed to advance research into NBS as a potential treatment for the symptoms and disabilities caused by AD and to enable comparison of results across trials. Ultimately, appropriately powered, and controlled, multi-site randomized clinical trials will be needed to evaluate the therapeutic potential of NBS in AD.

引用

页码：362 / 376

页数：15

共 120 条

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