Long Noncoding RNAs in Cell-Fate Programming and Reprogramming

被引：674

作者：

Flynn, Ryan A. ^{[1
,2
]}

Chang, Howard Y. ^{[1
,2
]}

机构：

[1] Stanford Univ, Sch Med, Howard Hughes Med Inst, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Program Epithelial Biol, Stanford, CA 94305 USA

来源：

CELL STEM CELL | 2014年 / 14卷 / 06期

关键词：

STEM-CELLS; SELF-RENEWAL; DIFFERENTIATION; GENE; CHROMATIN; PRC2; REVEALS; BINDING; TRANSCRIPTION; PLURIPOTENCY;

D O I：

10.1016/j.stem.2014.05.014

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

In recent years, long noncoding RNAs (IncRNAs) have emerged as an important class of regulators of gene expression. IncRNAs exhibit several distinctive features that confer unique regulatory functions, including exquisite cell-and tissue-specific expression and the capacity to transduce higher-order spatial information. Here we review evidence showing that lncRNAs exert critical functions in adult tissue stem cells, including skin, brain, and muscle, as well as in developmental patterning and pluripotency. We highlight new approaches for ascribing IncRNA functions and discuss mammalian dosage compensation as a classic example of an lncRNA network coupled to stem cell differentiation.

引用

页码：752 / 761

页数：10

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