Regulation of integrin-mediated cellular responses through assembly of a CAS/Crk scaffold

被引:144
作者
Chodniewicz, D [1 ]
Klemke, RL [1 ]
机构
[1] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA
来源
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2004年 / 1692卷 / 2-3期
关键词
Crk; Crk-associated substrate; migration; integrin; Abl; tyrosine phosphorylation;
D O I
10.1016/j.bbamcr.2004.03.006
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The molecular coupling of CAS and Crk in response to integrin activation is an evolutionary conserved signaling module that controls cell proliferation, survival and migration. However, when deregulated, CAS/Crk signaling also contributes to cancer progression and developmental defects in humans. Here we highlight recent advances in our understanding of how CAS/Crk complexes assemble in cells to modulate the actin cytoskeleton, and the molecular mechanisms that regulate this process. We discuss in detail the spatiotemporal dynamics of CAS/Crk assembly and how this scaffold recruits specific effector proteins that couple integrin signaling networks to the migration machinery of cells. We also highlight the importance of CAS/Crk signaling in the dual regulation of cell migration and survival mechanisms that operate in invasive cells during development and pathological conditions associated with cancer metastasis. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码:63 / 76
页数:14
相关论文
共 165 条
  • [51] PDGF STIMULATES AN INCREASE IN GTP-RAC VIA ACTIVATION OF PHOSPHOINOSITIDE 3-KINASE
    HAWKINS, PT
    EGUINOA, A
    QIU, RG
    STOKOE, D
    COOKE, FT
    WALTERS, R
    WENNSTROM, S
    CLAESSONWELSH, L
    EVANS, T
    SYMONS, M
    STEPHENS, L
    [J]. CURRENT BIOLOGY, 1995, 5 (04) : 393 - 403
  • [52] Gab-family adapter molecules in signal transduction of cytokine and growth factor receptors, and T and B cell antigen receptors
    Hibi, M
    Hirano, T
    [J]. LEUKEMIA & LYMPHOMA, 2000, 37 (3-4) : 299 - +
  • [53] Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas
    Honda, H
    Oda, H
    Nakamoto, T
    Honda, Z
    Sakai, R
    Suzuki, T
    Saito, T
    Nakamura, K
    Nakao, K
    Ishikawa, T
    Katsuki, M
    Yazaki, Y
    Hirai, H
    [J]. NATURE GENETICS, 1998, 19 (04) : 361 - 365
  • [54] Ishino M, 1995, ONCOGENE, V11, P2331
  • [55] CrkII induces serum response factor activation and cellular transformation through its function in Rho activation
    Iwahara, T
    Akagi, T
    Shishido, T
    Hanafusa, H
    [J]. ONCOGENE, 2003, 22 (38) : 5946 - 5957
  • [56] Cytoplasmic c-Abl provides a molecular 'rheostat' controlling carcinoma cell survival and invasion
    Kain, KH
    Gooch, S
    Klemke, RL
    [J]. ONCOGENE, 2003, 22 (38) : 6071 - 6080
  • [57] Inhibition of cell migration by Abl family tyrosine kinases through uncoupling of Crk-CAS complexes
    Kain, KH
    Klemke, RL
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (19) : 16185 - 16192
  • [58] Rac recruits high-affinity integrin αvβ3 to lamellipodia in endothelial cell migration
    Kiosses, WB
    Shattil, SJ
    Pampori, N
    Schwartz, MA
    [J]. NATURE CELL BIOLOGY, 2001, 3 (03) : 316 - 320
  • [59] Direct binding of p130Cas to the guanine nucleotide exchange factor C3G
    Kirsch, KH
    Georgescu, MM
    Hanafusa, H
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (40) : 25673 - 25679
  • [60] Role of Crk oncogene product in physiologic signaling
    Kiyokawa, E
    Mochizuki, N
    Kurata, T
    Matsuda, M
    [J]. CRITICAL REVIEWS IN ONCOGENESIS, 1997, 8 (04): : 329 - 342