The molecular coupling of CAS and Crk in response to integrin activation is an evolutionary conserved signaling module that controls cell proliferation, survival and migration. However, when deregulated, CAS/Crk signaling also contributes to cancer progression and developmental defects in humans. Here we highlight recent advances in our understanding of how CAS/Crk complexes assemble in cells to modulate the actin cytoskeleton, and the molecular mechanisms that regulate this process. We discuss in detail the spatiotemporal dynamics of CAS/Crk assembly and how this scaffold recruits specific effector proteins that couple integrin signaling networks to the migration machinery of cells. We also highlight the importance of CAS/Crk signaling in the dual regulation of cell migration and survival mechanisms that operate in invasive cells during development and pathological conditions associated with cancer metastasis. (C) 2004 Elsevier B.V. All rights reserved.
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Osaka Univ, Biomed Res Ctr, Grad Sch Med, Div Mol Oncol, Suita, Osaka 5650871, JapanOsaka Univ, Biomed Res Ctr, Grad Sch Med, Div Mol Oncol, Suita, Osaka 5650871, Japan
Hibi, M
Hirano, T
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Osaka Univ, Biomed Res Ctr, Grad Sch Med, Div Mol Oncol, Suita, Osaka 5650871, JapanOsaka Univ, Biomed Res Ctr, Grad Sch Med, Div Mol Oncol, Suita, Osaka 5650871, Japan
机构:Int Med Ctr Japan, Natl Inst Infect Dis, Dept Pathol, Shinjuku Ku, Tokyo 1628655, Japan
Kiyokawa, E
Mochizuki, N
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机构:Int Med Ctr Japan, Natl Inst Infect Dis, Dept Pathol, Shinjuku Ku, Tokyo 1628655, Japan
Mochizuki, N
Kurata, T
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机构:Int Med Ctr Japan, Natl Inst Infect Dis, Dept Pathol, Shinjuku Ku, Tokyo 1628655, Japan
Kurata, T
Matsuda, M
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Int Med Ctr Japan, Natl Inst Infect Dis, Dept Pathol, Shinjuku Ku, Tokyo 1628655, JapanInt Med Ctr Japan, Natl Inst Infect Dis, Dept Pathol, Shinjuku Ku, Tokyo 1628655, Japan
机构:
Osaka Univ, Biomed Res Ctr, Grad Sch Med, Div Mol Oncol, Suita, Osaka 5650871, JapanOsaka Univ, Biomed Res Ctr, Grad Sch Med, Div Mol Oncol, Suita, Osaka 5650871, Japan
Hibi, M
Hirano, T
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h-index: 0
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Osaka Univ, Biomed Res Ctr, Grad Sch Med, Div Mol Oncol, Suita, Osaka 5650871, JapanOsaka Univ, Biomed Res Ctr, Grad Sch Med, Div Mol Oncol, Suita, Osaka 5650871, Japan
机构:Int Med Ctr Japan, Natl Inst Infect Dis, Dept Pathol, Shinjuku Ku, Tokyo 1628655, Japan
Kiyokawa, E
Mochizuki, N
论文数: 0引用数: 0
h-index: 0
机构:Int Med Ctr Japan, Natl Inst Infect Dis, Dept Pathol, Shinjuku Ku, Tokyo 1628655, Japan
Mochizuki, N
Kurata, T
论文数: 0引用数: 0
h-index: 0
机构:Int Med Ctr Japan, Natl Inst Infect Dis, Dept Pathol, Shinjuku Ku, Tokyo 1628655, Japan
Kurata, T
Matsuda, M
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h-index: 0
机构:
Int Med Ctr Japan, Natl Inst Infect Dis, Dept Pathol, Shinjuku Ku, Tokyo 1628655, JapanInt Med Ctr Japan, Natl Inst Infect Dis, Dept Pathol, Shinjuku Ku, Tokyo 1628655, Japan