Synthesis and evaluation of a scintillant-containing solid support for use in combinatorial chemistry

被引:17
作者
Clapham, B
Sutherland, AJ
机构
[1] Aston Univ, Birmingham B4 7ET, W Midlands, England
[2] Nottingham Trent Univ, Dept Chem & Phys, Nottingham NG11 8NS, England
关键词
oxazoles; polymerisation; resins; combinatorial chemistry;
D O I
10.1016/S0040-4039(00)00141-6
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A scintillant monomer, 2,5-diphenyl-4-vinyloxazole, has been synthesised and co-polymerised with 4-ethylstyrene, divinylbenzene and 4-vinylbenzyl chloride in the presence of a toluene porogen, to form a scintillant-containing macroporous resin. Despite prolonged exposure to organic solvent, this resin retains the ability to scintillate efficiently in the presence of ionising radiation. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:2253 / 2256
页数:4
相关论文
共 15 条
[1]   SCINTILLATION PROXIMITY ASSAY [J].
BOSWORTH, N ;
TOWERS, P .
NATURE, 1989, 341 (6238) :167-168
[2]   Synthesis and scintillating efficiencies of 4-functionalised-2,5-diphenyloxazoles [J].
Clapham, B ;
Richards, AJ ;
Wood, ML ;
Sutherland, AJ .
TETRAHEDRON LETTERS, 1997, 38 (52) :9061-9064
[3]   Use of a scintillant-containing macroporous resin in both solid phase synthesis and subsequent on-bead scintillation-based analysis [J].
Clapham, B ;
Sutherland, AJ .
TETRAHEDRON LETTERS, 2000, 41 (13) :2257-2260
[4]  
Dyer A., 1974, INTRO LIQUID SCINTIL, P12
[5]   A MILD OXIDIZING REAGENT FOR ALCOHOLS AND 1,2-DIOLS - O-IODOXYBENZOIC ACID (IBX) IN DMSO [J].
FRIGERIO, M ;
SANTAGOSTINO, M .
TETRAHEDRON LETTERS, 1994, 35 (43) :8019-8022
[6]   OXIDATION OF ALCOHOLS WITH O-IODOXYBENZOIC ACID (IBX) IN DMSO - A NEW INSIGHT INTO AN OLD HYPERVALENT IODINE REAGENT [J].
FRIGERIO, M ;
SANTAGOSTINO, M ;
SPUTORE, S ;
PALMISANO, G .
JOURNAL OF ORGANIC CHEMISTRY, 1995, 60 (22) :7272-7276
[7]   A user-friendly entry to 2-iodoxybenzoic acid (IBX) [J].
Frigerio, M ;
Santagostino, M ;
Sputore, S .
JOURNAL OF ORGANIC CHEMISTRY, 1999, 64 (12) :4537-4538
[8]   CHARACTERIZATION OF A SCINTILLATION PROXIMITY ASSAY TO DETECT MODULATORS OF TRANSFORMING GROWTH FACTOR-ALPHA (TGF-ALPHA) BINDING [J].
HOFFMAN, R ;
CAMERON, L .
ANALYTICAL BIOCHEMISTRY, 1992, 203 (01) :70-75
[9]   THE WITTIG OLEFINATION REACTION AND MODIFICATIONS INVOLVING PHOSPHORYL-STABILIZED CARBANIONS - STEREOCHEMISTRY, MECHANISM, AND SELECTED SYNTHETIC ASPECTS [J].
MARYANOFF, BE ;
REITZ, AB .
CHEMICAL REVIEWS, 1989, 89 (04) :863-927
[10]   PREPARATION, MODIFICATION AND CHARACTERIZATION OF POLYMER-SUPPORTED SPECIES [J].
SHERRINGTON, DC .
BRITISH POLYMER JOURNAL, 1984, 16 (04) :164-172