Dendrimer-based nanoprobe for dual modality magnetic resonance and fluorescence imaging

被引：203

作者：

Talanov, Vladimir S. ^{[1
]}

Regino, Celeste A. S. ^{[1
]}

Kobayashi, Hisataka ^{[1
]}

Bernardo, Marcelino ^{[1
]}

Choyke, Peter L. ^{[1
]}

Brechbiel, Martin W. ^{[1
]}

机构：

[1] NCI, Radioimmune & Inorgan Chem Sect, Radiat Oncol Branch, NIH,Mol Imaging Program, Bethesda, MD 20892 USA

来源：

NANO LETTERS | 2006年 / 6卷 / 07期

关键词：

BIOMEDICAL APPLICATIONS; PAMAM DENDRIMERS; QUANTUM YIELDS; NANODEVICE; DELIVERY; THERAPY; CANCER; AGENTS; SIZE;

D O I：

10.1021/nl060765q

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel PAMAM dendrimer-based nanoprobe for dual magnetic resonance and fluorescence imaging modalities was synthesized. Fluorescence studies revealed that Gd(III) complexation to the probe has no effect on the quantum yield; however, increases in the dye content resulted in partial quenching. The potential of the new nanoprobe, G6-(Cy5.5)(1.25)(1B4M-Gd)(145), as a dual modality imaging agent was demonstrated in vivo by the efficient visualization of sentinel lymph nodes in mice by both MRI and fluorescence imaging modalities.

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收藏

页码：1459 / 1463

页数：5

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