Oxamyl dipeptide caspase inhibitors developed for the treatment of stroke

被引：18

作者：

Linton, SD

Aja, T

Allegrini, PR

Deckwerth, TL

Diaz, JL

Hengerer, B

Herrmann, J

Jahangiri, KG

Kallen, J

Karanewsky, DS

Meduna, SP

Nalley, K

Robinson, ED

Roggo, S

Rovelli, G

Sauter, A

Sayers, RO

Schmitz, A

Smidt, R

Ternansky, RJ

Tomaselli, KJ

Ullman, BR

Wiessner, C

Wu, JC

机构：

[1] Idun Pharmaceut Inc, San Diego, CA 92121 USA

[2] Novartis Pharma Ltd, Pharma Res, CH-4002 Basel, Switzerland

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 10期

关键词：

D O I：

10.1016/j.bmcl.2003.12.106

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Structural modifications were made to a previously described acyl dipeptide caspase inhibitor, leading to the oxamyl dipeptide series. Subsequent SAR studies directed toward the warhead, P2, and P4 regions of this novel peptidomimetic are described herein. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：2685 / 2691

页数：7

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