Cell-based therapies in Parkinson's disease

被引：24

作者：

Greene, Paul ^{[1
]}

机构：

[1] Columbia Univ, Med Ctr, Dept Neurol, New York, NY 10032 USA

来源：

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS | 2009年 / 9卷 / 04期

关键词：

FETAL NIGRAL TRANSPLANTATION; RANDOMIZED CONTROLLED-TRIAL; TISSUE-TRANSPLANTATION; DOPAMINERGIC-NEURONS; GROWTH-FACTOR; RAT MODEL; NERVE; NEUROPROTECTION; AUTOGRAFTS; DYSKINESIA;

D O I：

10.1007/s11910-009-0044-3

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The possibility of using stem cells to treat Parkinson's disease has excited physicians and patients alike. However, after many encouraging open-label studies of fetal cell transplantation for Parkinson's disease, three randomized, double-blind, placebo-controlled studies found no net benefit. In addition, patients in two of the studies developed dyskinesias that persisted despite reductions in medication. To realize the promise of stem cells, research has been undertaken to understand and overcome the dual problems of unpredictable benefit and troublesome dyskinesias after dopaminergic cell transplantation.

引用

页码：292 / 297

页数：6

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