Tau function and dysfunction in neurons - Its role in neurodegenerative disorders

被引：51

作者：

Avila, J ^{[1
]}

Lim, F

Moreno, F

Belmonte, C

Cuello, AC

机构：

[1] Univ Autonoma Madrid, CSIC, Ctr Biol Mol, E-28049 Madrid, Spain

[2] Univ Miguel Hernandez, Inst Neurociencias, Alicante, Spain

[3] McGill Univ, Dept Pharm & Therapeut, Montreal, PQ H3G 1Y6, Canada

[4] McGill Univ, Dept Anat & Cell Biol, Montreal, PQ H3G 1Y6, Canada

[5] McGill Univ, Dept Med, Montreal, PQ H3G 1Y6, Canada

来源：

MOLECULAR NEUROBIOLOGY | 2002年 / 25卷 / 03期

关键词：

tau; hyperphosphorylated tau; paired helical filaments; neurofibrillary tangles; Alzheimer's disease; tauopathies; transgenic animal models; tau polymerization;

D O I：

10.1385/MN:25:3:213

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alzheimer's disease (AD) is the most usual neurodegenerative disorder leading to dementia in the aged human population. It is characterized by the presence of two main brain pathological hallmarks: senile plaques and neurofibrillary tangles (NFTs). NFTs are composed of fibrillar polymers of the abnormally phosphorylated cytoskeletal protein tau.

引用

页码：213 / 231

页数：19

共 185 条

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