c-Src and cooperating partners in human cancer

被引:499
作者
Ishizawar, R
Parsons, SJ
机构
[1] Univ Virginia Hlth Syst, Ctr Canc, Charlottesville, VA 22908 USA
[2] Univ Virginia Hlth Syst, Dept Microbiol, Charlottesville, VA 22908 USA
关键词
D O I
10.1016/j.ccr.2004.09.001
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The proto-oncogene c-src is rarely mutated in human cancers, and when overexpressed in normal cells is non- or weakly oncogenic. These observations have raised doubts about the involvement of c-src in the etiology of human tumors. However, recent studies have shown that c-Src, a non-receptor tyrosine kinase, exhibits elevated protein levels and activity in numerous types of human cancers. Furthermore, it has been found to be a critical component of multiple signaling pathways that regulate proliferation, survival, metastasis, and angiogenesis. Because of its important role in these oncogenic processes, it represents a therapeutic target ripe for exploitation.
引用
收藏
页码:209 / 214
页数:6
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