共 63 条
c-Src and cooperating partners in human cancer
被引:499
作者:

Ishizawar, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Virginia Hlth Syst, Ctr Canc, Charlottesville, VA 22908 USA

Parsons, SJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Virginia Hlth Syst, Ctr Canc, Charlottesville, VA 22908 USA
机构:
[1] Univ Virginia Hlth Syst, Ctr Canc, Charlottesville, VA 22908 USA
[2] Univ Virginia Hlth Syst, Dept Microbiol, Charlottesville, VA 22908 USA
来源:
关键词:
D O I:
10.1016/j.ccr.2004.09.001
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
The proto-oncogene c-src is rarely mutated in human cancers, and when overexpressed in normal cells is non- or weakly oncogenic. These observations have raised doubts about the involvement of c-src in the etiology of human tumors. However, recent studies have shown that c-Src, a non-receptor tyrosine kinase, exhibits elevated protein levels and activity in numerous types of human cancers. Furthermore, it has been found to be a critical component of multiple signaling pathways that regulate proliferation, survival, metastasis, and angiogenesis. Because of its important role in these oncogenic processes, it represents a therapeutic target ripe for exploitation.
引用
收藏
页码:209 / 214
页数:6
相关论文
共 63 条
[11]
Regulation of c-SRC activity and function by the adapter protein CAS
[J].
Burnham, MR
;
Bruce-Staskal, PJ
;
Harte, MT
;
Weidow, CL
;
Ma, A
;
Weed, SA
;
Bouton, AH
.
MOLECULAR AND CELLULAR BIOLOGY,
2000, 20 (16)
:5865-5878

Burnham, MR
论文数: 0 引用数: 0
h-index: 0
机构: Univ Virginia, Hlth Sci Ctr, Dept Microbiol, Charlottesville, VA 22908 USA

Bruce-Staskal, PJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Virginia, Hlth Sci Ctr, Dept Microbiol, Charlottesville, VA 22908 USA

Harte, MT
论文数: 0 引用数: 0
h-index: 0
机构: Univ Virginia, Hlth Sci Ctr, Dept Microbiol, Charlottesville, VA 22908 USA

Weidow, CL
论文数: 0 引用数: 0
h-index: 0
机构: Univ Virginia, Hlth Sci Ctr, Dept Microbiol, Charlottesville, VA 22908 USA

Ma, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Virginia, Hlth Sci Ctr, Dept Microbiol, Charlottesville, VA 22908 USA

Weed, SA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Virginia, Hlth Sci Ctr, Dept Microbiol, Charlottesville, VA 22908 USA

Bouton, AH
论文数: 0 引用数: 0
h-index: 0
机构: Univ Virginia, Hlth Sci Ctr, Dept Microbiol, Charlottesville, VA 22908 USA
[12]
Focal adhesions, contractility, and signaling
[J].
Burridge, K
;
ChrzanowskaWodnicka, M
.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY,
1996, 12
:463-518

Burridge, K
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV N CAROLINA, LINEBERGER COMPREHENS CANC CTR, CHAPEL HILL, NC 27599 USA UNIV N CAROLINA, LINEBERGER COMPREHENS CANC CTR, CHAPEL HILL, NC 27599 USA

ChrzanowskaWodnicka, M
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV N CAROLINA, LINEBERGER COMPREHENS CANC CTR, CHAPEL HILL, NC 27599 USA UNIV N CAROLINA, LINEBERGER COMPREHENS CANC CTR, CHAPEL HILL, NC 27599 USA
[13]
Lessons learned from the development of an Abl tyrosine kinase inhibitor for chronic myelogenous leukemia
[J].
Druker, BJ
;
Lydon, NB
.
JOURNAL OF CLINICAL INVESTIGATION,
2000, 105 (01)
:3-7

Druker, BJ
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Div Hematol & Med Oncol, Portland, OR 97201 USA

Lydon, NB
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Div Hematol & Med Oncol, Portland, OR 97201 USA
[14]
Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF
[J].
Filardo, EJ
;
Quinn, JA
;
Bland, KI
;
Frackelton, AR
.
MOLECULAR ENDOCRINOLOGY,
2000, 14 (10)
:1649-1660

Filardo, EJ
论文数: 0 引用数: 0
h-index: 0
机构: Rhode Isl Hosp, Dept Med & Surg, Providence, RI 02903 USA

Quinn, JA
论文数: 0 引用数: 0
h-index: 0
机构: Rhode Isl Hosp, Dept Med & Surg, Providence, RI 02903 USA

Bland, KI
论文数: 0 引用数: 0
h-index: 0
机构: Rhode Isl Hosp, Dept Med & Surg, Providence, RI 02903 USA

Frackelton, AR
论文数: 0 引用数: 0
h-index: 0
机构: Rhode Isl Hosp, Dept Med & Surg, Providence, RI 02903 USA
[15]
The ErbB receptors and their role in cancer progression
[J].
Holbro, T
;
Civenni, G
;
Hynes, NE
.
EXPERIMENTAL CELL RESEARCH,
2003, 284 (01)
:99-110

Holbro, T
论文数: 0 引用数: 0
h-index: 0
机构:
Friedrich Miescher Inst, CH-4002 Basel, Switzerland Friedrich Miescher Inst, CH-4002 Basel, Switzerland

论文数: 引用数:
h-index:
机构:

Hynes, NE
论文数: 0 引用数: 0
h-index: 0
机构:
Friedrich Miescher Inst, CH-4002 Basel, Switzerland Friedrich Miescher Inst, CH-4002 Basel, Switzerland
[16]
Role of Src expression and activation in human cancer
[J].
Irby, RB
;
Yeatman, TJ
.
ONCOGENE,
2000, 19 (49)
:5636-5642

Irby, RB
论文数: 0 引用数: 0
h-index: 0
机构:
Univ S Florida, H Lee Moffitt Canc Ctr & Res Inst, Dept Surg, Tampa, FL 33612 USA Univ S Florida, H Lee Moffitt Canc Ctr & Res Inst, Dept Surg, Tampa, FL 33612 USA

Yeatman, TJ
论文数: 0 引用数: 0
h-index: 0
机构:
Univ S Florida, H Lee Moffitt Canc Ctr & Res Inst, Dept Surg, Tampa, FL 33612 USA Univ S Florida, H Lee Moffitt Canc Ctr & Res Inst, Dept Surg, Tampa, FL 33612 USA
[17]
Activating SRC mutation in a subset of advanced human colon cancers
[J].
Irby, RB
;
Mao, WG
;
Coppola, D
;
Kang, J
;
Loubeau, JM
;
Trudeau, W
;
Karl, R
;
Fujita, DJ
;
Jove, R
;
Yeatman, TJ
.
NATURE GENETICS,
1999, 21 (02)
:187-190

Irby, RB
论文数: 0 引用数: 0
h-index: 0
机构: Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Dept Surg, Tampa, FL 33612 USA

Mao, WG
论文数: 0 引用数: 0
h-index: 0
机构: Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Dept Surg, Tampa, FL 33612 USA

Coppola, D
论文数: 0 引用数: 0
h-index: 0
机构: Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Dept Surg, Tampa, FL 33612 USA

Kang, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Dept Surg, Tampa, FL 33612 USA

Loubeau, JM
论文数: 0 引用数: 0
h-index: 0
机构: Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Dept Surg, Tampa, FL 33612 USA

Trudeau, W
论文数: 0 引用数: 0
h-index: 0
机构: Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Dept Surg, Tampa, FL 33612 USA

Karl, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Dept Surg, Tampa, FL 33612 USA

Fujita, DJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Dept Surg, Tampa, FL 33612 USA

Jove, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Dept Surg, Tampa, FL 33612 USA

Yeatman, TJ
论文数: 0 引用数: 0
h-index: 0
机构:
Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Dept Surg, Tampa, FL 33612 USA Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Dept Surg, Tampa, FL 33612 USA
[18]
ASSOCIATION OF THE AMINO-TERMINAL HALF OF C-SRC WITH FOCAL ADHESIONS ALTERS THEIR PROPERTIES AND IS REGULATED BY PHOSPHORYLATION OF TYROSINE-527
[J].
KAPLAN, KB
;
BIBBINS, KB
;
SWEDLOW, JR
;
ARNAUD, M
;
MORGAN, DO
;
VARMUS, HE
.
EMBO JOURNAL,
1994, 13 (20)
:4745-4756

KAPLAN, KB
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF SAN FRANCISCO, DEPT PHYSIOL, SAN FRANCISCO, CA 94143 USA

BIBBINS, KB
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF SAN FRANCISCO, DEPT PHYSIOL, SAN FRANCISCO, CA 94143 USA

SWEDLOW, JR
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF SAN FRANCISCO, DEPT PHYSIOL, SAN FRANCISCO, CA 94143 USA

ARNAUD, M
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF SAN FRANCISCO, DEPT PHYSIOL, SAN FRANCISCO, CA 94143 USA

MORGAN, DO
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF SAN FRANCISCO, DEPT PHYSIOL, SAN FRANCISCO, CA 94143 USA

VARMUS, HE
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF SAN FRANCISCO, DEPT PHYSIOL, SAN FRANCISCO, CA 94143 USA
[19]
Inhibition of pp60c-Src reduces Bcl-XL expression and reverses the transformed phenotype of cells overexpressing EGF and HER-2 receptors
[J].
Karni, R
;
Jove, R
;
Levitzki, A
.
ONCOGENE,
1999, 18 (33)
:4654-4662

Karni, R
论文数: 0 引用数: 0
h-index: 0
机构: Hebrew Univ Jerusalem, Alexander Silberman Inst Life Sci, Dept Biol Chem, IL-91904 Jerusalem, Israel

Jove, R
论文数: 0 引用数: 0
h-index: 0
机构: Hebrew Univ Jerusalem, Alexander Silberman Inst Life Sci, Dept Biol Chem, IL-91904 Jerusalem, Israel

Levitzki, A
论文数: 0 引用数: 0
h-index: 0
机构:
Hebrew Univ Jerusalem, Alexander Silberman Inst Life Sci, Dept Biol Chem, IL-91904 Jerusalem, Israel Hebrew Univ Jerusalem, Alexander Silberman Inst Life Sci, Dept Biol Chem, IL-91904 Jerusalem, Israel
[20]
STAT5b, a mediator of synergism between c-Src and the epidermal growth factor receptor
[J].
Kloth, MT
;
Laughlin, KK
;
Biscardi, JS
;
Boerner, JL
;
Parsons, SJ
;
Silva, CM
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
2003, 278 (03)
:1671-1679

Kloth, MT
论文数: 0 引用数: 0
h-index: 0
机构: Univ Virginia, Hth Syst, Dept Internal Med, Charlottesville, VA 22908 USA

Laughlin, KK
论文数: 0 引用数: 0
h-index: 0
机构: Univ Virginia, Hth Syst, Dept Internal Med, Charlottesville, VA 22908 USA

Biscardi, JS
论文数: 0 引用数: 0
h-index: 0
机构: Univ Virginia, Hth Syst, Dept Internal Med, Charlottesville, VA 22908 USA

Boerner, JL
论文数: 0 引用数: 0
h-index: 0
机构: Univ Virginia, Hth Syst, Dept Internal Med, Charlottesville, VA 22908 USA

Parsons, SJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Virginia, Hth Syst, Dept Internal Med, Charlottesville, VA 22908 USA

Silva, CM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Virginia, Hth Syst, Dept Internal Med, Charlottesville, VA 22908 USA