c-Src and cooperating partners in human cancer

被引：499

作者：

Ishizawar, R

Parsons, SJ

机构：

[1] Univ Virginia Hlth Syst, Ctr Canc, Charlottesville, VA 22908 USA

[2] Univ Virginia Hlth Syst, Dept Microbiol, Charlottesville, VA 22908 USA

来源：

CANCER CELL | 2004年 / 6卷 / 03期

关键词：

D O I：

10.1016/j.ccr.2004.09.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The proto-oncogene c-src is rarely mutated in human cancers, and when overexpressed in normal cells is non- or weakly oncogenic. These observations have raised doubts about the involvement of c-src in the etiology of human tumors. However, recent studies have shown that c-Src, a non-receptor tyrosine kinase, exhibits elevated protein levels and activity in numerous types of human cancers. Furthermore, it has been found to be a critical component of multiple signaling pathways that regulate proliferation, survival, metastasis, and angiogenesis. Because of its important role in these oncogenic processes, it represents a therapeutic target ripe for exploitation.

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收藏

页码：209 / 214

页数：6

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