A steric control of regioselectivity in palladium-catalyzed cyclizations of alkenes bearing arylbromides and nucleophiles

被引：30

作者：

Bruyere, D

Gaignard, G

Bouyssi, D

Balme, G

Lancelin, JM

机构：

[1] UNIV LYON 1,CPE,CNRS,LAB CHIM ORGAN 1,F-69622 VILLEURBANNE,FRANCE

[2] UNIV LYON 1,CNRS,LAB RMN BIOMOL,CPE,F-69622 VILLEURBANNE,FRANCE

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 05期

关键词：

D O I：

10.1016/S0040-4039(96)02442-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The stereocontrolled synthesis of tricyclic compounds through an efficient and highly regioselective 5-exo-trig palladium catalyzed biscyclization process is reported, starting from compounds 1. The 6-endo competing cyclization can also be the only pathway leading to trans-octahydrophenanthrene. In this finely balanced competition, it appeared that the B-endo to 5-exo ratio is dependent upon the size of the nucleophilic part of the starting material. (C) 1997, Published by Elsevier Science Ltd.

引用

页码：827 / 830

页数：4

共 13 条

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