Inhibitory effects of arbutin on melanin biosynthesis of α-melanocyte stimulating hormone-induced hyperpigmentation in cultured brownish guinea pig skin tissues

被引：136

作者：

Lim, Yu-Ji ^{[1
]}

Lee, Eunjoo H. ^{[1
]}

Kang, Tong Ho ^{[2
]}

Ha, Sang Keun ^{[1
]}

Oh, Myung Sook ^{[3
,4
]}

Kim, Seong Min ^{[5
]}

Yoon, Tae-Jin ^{[5
]}

Kang, Chulhun ^{[1
]}

Park, Ji-Ho ^{[1
]}

Kim, Sun Yeou ^{[1
,6
]}

机构：

[1] Kyung Hee Univ, Dept Med Sci, Grad Sch EW Med Sci, Yongin 449701, South Korea

[2] Kyung Hee Univ, Coll Life Sci, Dept Oriental Med Mat & Proc, Yongin 446701, South Korea

[3] Kyung Hee Univ, Coll Pharm, Dept Oriental Pharmaceut Sci, Seoul 130701, South Korea

[4] Kyung Hee Univ, Coll Pharm, Kyung Hee EW Pharmaceut Res Inst, Seoul 130701, South Korea

[5] Gyeongsang Natl Univ, Sch Med, Dept Dermatol, Jinju 660751, South Korea

[6] Kyung Hee Univ, Skin Biotechnol Res Ctr, Yongin 449701, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2009年 / 32卷 / 03期

关键词：

alpha-MSH; Arbutin; Hyperpigmentation; Melanin; Melanocyte; Melanogenesis; Skin tissue culture; Tyrosinase; TRP-1; TRP-2; TYROSINASE ACTIVITY; PIGMENTATION; CELLS; ACID; MELANOGENESIS; MECHANISM; MODEL;

D O I：

10.1007/s12272-009-1309-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Arbutin has been used as a whitening agent in cosmetic products. Melanin, the major pigment that gives color to skin, may be over-produced with sun exposure or in conditions such as melasma or hyperpigmentary diseases. Tyrosinase is a key enzyme that catalyzes melanin synthesis in melanocytes; therefore, inhibitors of the tyrosinase enzyme could be used for cosmetic skin whitening. A recent study has reported that arbutin decreases melanin biosynthesis through the inhibition of tyrosinase activity. However, this inhibitory mechanism of arbutin was not sufficiently demonstrated in skin tissue models. We found that arbutin both inhibits melanin production in B16 cells induced with alpha-MSH and decreases tyrosinase activity in a cell-free system. Furthermore, the hyperpigmentation effects of alpha-MSH were abrogated by the addition of arbutin to brownish guinea pig and human skin tissues. These results suggest that arbutin may be a useful agent for skin whitening.

引用

页码：367 / 373

页数：7

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