Sodium valproate vs phenytoin in status epilepticus: A pilot study

被引：178

作者：

Misra, U. K. ^{[1
]}

Kalita, Jayantee ^{[1
]}

Patel, Rajesh ^{[1
]}

机构：

[1] Sanjay Gandhi Postgrad Inst Med Sci, Dept Neurol, Lucknow 226014, Uttar Pradesh, India

来源：

NEUROLOGY | 2006年 / 67卷 / 02期

关键词：

D O I：

10.1212/01.wnl.0000224880.35053.26

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Sixty-eight patients with convulsive status epilepticus (SE) were randomly assigned to two groups to study the efficacy of sodium valproate (VPA) and phenytoin (PHT). Seizures were aborted in 66% in the VPA group and 42% in the PHT group. As a second choice in refractory patients, VPA was effective in 79% and PHT was effective in 25%. The side effects in the two groups did not differ. Sodium valproate may be preferred in convulsive SE because of its higher efficacy.

引用

页码：340 / 342

页数：3

共 9 条

[1] Status epilepticus in children experience with intravenous valproate.: Update of treatment guidelines [J].

Campistol, J ;

Fernández, A ;

Ortega, J .

REVISTA DE NEUROLOGIA, 1999, 29 (04) :359-365

[2] USE OF INJECTABLE VALPROIC ACID IN STATUS EPILEPTICUS - A PILOT-STUDY [J].

GIROUD, M ;

GRAS, D ;

ESCOUSSE, A ;

DUMAS, R ;

VENAUD, G .

DRUG INVESTIGATION, 1993, 5 (03) :154-159

[3] Efficacy of rapid IV administration of valproic acid for status epilepticus [J].

Limdi, NA ;

Shimpi, AV ;

Faught, E ;

Gomez, CR ;

Burneo, JG .

NEUROLOGY, 2005, 64 (02) :353-355

[4] Guidelines for nonemergency use of parenteral phenytoin products -: Proceedings of an expert panel consensus process [J].

Meek, PD ;

Davis, SN ;

Collins, M ;

Gidal, BE ;

Rutecki, PA ;

Burstein, AH ;

Fischer, JH ;

Leppik, IE ;

Ramsay, RE .

ARCHIVES OF INTERNAL MEDICINE, 1999, 159 (22) :2639-2644

[5] Intravenous valproate is well tolerated in unstable patients with status epilepticus [J].

Sinha, S ;

Naritoku, DK .

NEUROLOGY, 2000, 55 (05) :722-724

[6] DETERMINANTS OF MORTALITY IN STATUS EPILEPTICUS [J].

TOWNE, AR ;

PELLOCK, JM ;

KO, DJ ;

DELORENZO, RJ .

EPILEPSIA, 1994, 35 (01) :27-34

[7] A comparison of four treatments for generalized convulsive status epilepticus [J].

Treiman, DM ;

Meyers, PD ;

Walton, NY ;

Collins, JF ;

Colling, C ;

Rowan, AJ ;

Handforth, A ;

Faught, E ;

Calabrese, VP ;

Uthman, BM ;

Ramsay, RE ;

Mamdani, MB .

NEW ENGLAND JOURNAL OF MEDICINE, 1998, 339 (12) :792-798

[8] Intravenous valproate in pediatric epilepsy patients with refractory status epilepticus [J].

Überall, MA ;

Trollmann, R ;

Wunsiedler, U ;

Wenzel, D .

NEUROLOGY, 2000, 54 (11) :2188-2189

[9] Safety of rapid intravenous infusion of valproate loading doses in epilepsy patients [J].

Venkataraman, V ;

Wheless, JW .

EPILEPSY RESEARCH, 1999, 35 (02) :147-153

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