A new approach to the synthesis of podophyllotoxin based on epimerization reactions

被引：33

作者：

Medarde, M

Ramos, AC

Caballero, E

Lopez, JL

deClairac, RPL

SanFeliciano, A

机构：

[1] Lab. de Quim. Organ. y Farmaceut., Facultad de Farmacia, E-37007 Salamanca, Av. Campo Charro s/n

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 15期

关键词：

D O I：

10.1016/0040-4039(96)00355-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A formal synthesis of podophyllotoxin has been achieved by means of the well known conjugate addition-alkylation of 5H-furan-2-one, followed by cyclization and controlled epimerizations. This approach represents a useful new route to the 8,7'-trans-stereochemistry of aryltetralin lactones, that in other methodologies requires the opening and reclosure of the lacton ring. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：2663 / 2666

页数：4

共 59 条

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