Regulation of THI differentiation -: controlling the controllers

被引：79

作者：

O'Shea, JJ ^{[1
]}

Paul, WE

机构：

[1] NIAMSD, Mol Immunol & Inflammat Branch, NIH, Bethesda, MD 20892 USA

[2] NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA

来源：

NATURE IMMUNOLOGY | 2002年 / 3卷 / 06期

关键词：

D O I：

10.1038/ni0602-506

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Although cytokines and STATs are accepted as being integral to T(H)1 differentiation, T-bet had emerged as a possible master control switch. Fresh data forces a reexamination of the factors that control T-H cell development.

引用

页码：506 / 508

页数：4

共 12 条

[1] T-bet is a STAT1-induced regulator of IL-12R expression in naive CD4+ T cells [J].

Afkarian, M ;

Sedy, JR ;

Yang, J ;

Jacobson, NG ;

Cereb, N ;

Yang, SY ;

Murphy, TL ;

Murphy, KM .

NATURE IMMUNOLOGY, 2002, 3 (06) :549-557

[2] T helper subset development: roles of instruction, selection, and transcription [J].

Farrar, JD ;

Asnagli, H ;

Murphy, KM .

JOURNAL OF CLINICAL INVESTIGATION, 2002, 109 (04) :431-435

[3] Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet [J].

Finotto, S ;

Neurath, MF ;

Glickman, JN ;

Qin, SX ;

Lehr, HA ;

Green, FHY ;

Ackerman, K ;

Haley, K ;

Gatte, PR ;

Szabo, SJ ;

Drazen, JM ;

De Sanctis, GT ;

Glimcher, LH .

SCIENCE, 2002, 295 (5553) :336-338

[4] Transcription: Tantalizing times for T cells [J].

Ho, IC ;

Glimcher, LH .

CELL, 2002, 109 :S109-S120

[5] T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells [J].

Lighvani, AA ;

Frucht, DM ;

Jankovic, D ;

Yamane, H ;

Aliberti, J ;

Hissong, BD ;

Nguyen, BV ;

Gadina, M ;

Sher, A ;

Paul, WE ;

O'Shea, JJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (26) :15137-15142

[6] Role of T-bet in commitment of TH1 cells before IL-12-dependent selection [J].

Mullen, AC ;

High, FA ;

Hutchins, AS ;

Lee, HW ;

Villarino, AV ;

Livingston, DM ;

Kung, AL ;

Cereb, N ;

Yao, TP ;

Yang, SY ;

Reiner, SL .

SCIENCE, 2001, 292 (5523) :1907-1910

[7] Cytokine signaling in 2002: New surprises in the Jak/Stat pathway [J].

O'Shea, JJ ;

Gadina, M ;

Schreiber, RD .

CELL, 2002, 109 :S121-S131

[8] A novel transcription factor, T-bet, directs Th1 lineage commitment [J].

Szabo, SJ ;

Kim, ST ;

Costa, GL ;

Zhang, XK ;

Fathman, CG ;

Glimcher, LH .

CELL, 2000, 100 (06) :655-669

[9] Distinct effects of T-bet in TH1 lineage commitment and IFN-γ production in CD4 and CD8 T cells [J].

Szabo, SJ ;

Sullivan, BM ;

Stemmann, C ;

Satoskar, AR ;

Sleckman, BP ;

Glimcher, LH .

SCIENCE, 2002, 295 (5553) :338-342

[10] The biology of Stat4 and Stat6 [J].

Wurster, AL ;

Tanaka, T ;

Grusby, MJ .

ONCOGENE, 2000, 19 (21) :2577-2584

← 1 2 →