In vivo immunosuppressive activity of some cyclolignans

被引：50

作者：

Gordaliza, M ^{[1
]}

Castro, MA ^{[1
]}

delCorral, JMM ^{[1
]}

LopezVazquez, ML ^{[1
]}

SanFeliciano, A ^{[1
]}

Faircloth, GT ^{[1
]}

机构：

[1] PHARMAMAR USA INC, CAMBRIDGE, MA 02139 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 21期

关键词：

D O I：

10.1016/S0960-894X(97)10072-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several podophyllotoxin-related cyclolignans, either lacking the lactone ring or the methylenedioxy grouping, have been prepared and evaluated for their immunosuppressive (IMS) activity in the mouse allogeneic MLR in vitro test and in the in vivo techniques Graft vs Host Reaction (GVHR) and Skin Grafting (SG). The results obtained show that three cyclolignans fairly prevent splenomegaly in comparison with control animals and also promoted tolerance to grafting, being the first time that the in vivo LMS activity of cyclolignas is reported. (C) 1997 Elsevier Science Ltd.

引用

页码：2781 / 2786

页数：6

共 29 条

[1]

AYERS DC, 1990, LIGNANS CHEM BIOL CL

[2]

BEARD AR, 1987, ANTI-CANCER DRUG DES, V2, P247

[3]

Borel JF, 1982, CYCLOSPORINE A, P5

[4] THERMAL CHEMISTRY OF PODOPHYLLOTOXIN IN ETHANOL AND A COMPARISON OF THE CYTOSTATIC ACTIVITY OF THE THERMOLYSIS PRODUCTS [J].

BUCHARDT, O ;

JENSEN, RB ;

HANSEN, HF ;

NIELSEN, PE ;

ANDERSEN, D ;

CHINOIN, I .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1986, 75 (11) :1076-1080

[5] RENAL-TRANSPLANTATION IN YOUNG-CHILDREN [J].

BURREN, CP ;

JONES, CL ;

FRANCIS, DMA ;

POWELL, HR ;

WALKER, RG .

AUSTRALIAN AND NEW ZEALAND JOURNAL OF MEDICINE, 1995, 25 (02) :122-126

[6] ANTINEOPLASTIC AND ANTIVIRAL ACTIVITIES OF SOME CYCLOLIGNANS [J].

FELICIANO, AS ;

GORDALIZA, M ;

DELCORRAL, JMM ;

CASTRO, MA ;

GARCIAGRAVALOS, MD ;

RUIZLAZARO, P .

PLANTA MEDICA, 1993, 59 (03) :246-249

[7]

FENTREN GM, 1992, NEW ENGL J MED, V326, P1654

[8] Potent immunosuppressants, 2-alkyl-2-aminopropane-1,3-diols [J].

Fujita, T ;

Hirose, R ;

Yoneta, M ;

Sasaki, S ;

Inoue, K ;

Kiuchi, M ;

Hirase, S ;

Chiba, K ;

Sakamoto, H ;

Arita, M .

JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (22) :4451-4459

[9] FUNGAL METABOLITES .11. A POTENT IMMUNOSUPPRESSIVE ACTIVITY FOUND IN ISARIA-SINCLAIRII METABOLITE [J].

FUJITA, T ;

INOUE, K ;

YAMAMOTO, S ;

IKUMOTO, T ;

SASAKI, S ;

TOYAMA, R ;

CHIBA, K ;

HOSHINO, Y ;

OKUMOTO, T .

JOURNAL OF ANTIBIOTICS, 1994, 47 (02) :208-215

[10] SYNTHESIS AND EVALUATION OF PYRAZOLIGNANS - A NEW CLASS OF CYTOTOXIC AGENTS [J].

GORDALIZA, M ;

DELCORRAL, JMM ;

CASTRO, MA ;

LOPEZVAZQUEZ, ML ;

FELICIANO, AS ;

GARCIAGRAVALOS, MD ;

CARPY, A .

BIOORGANIC & MEDICINAL CHEMISTRY, 1995, 3 (09) :1203-1210

← 1 2 3 →