Pathogenic roles of B cells in human autoimmunity: Insights from the clinic

被引：179

作者：

Martin, F

Chan, AC

机构：

[1] Genentech Inc, Dept Immunol, San Francisco, CA 94080 USA

[2] Genentech Inc, Dept Antibody Engn, San Francisco, CA 94080 USA

来源：

IMMUNITY | 2004年 / 20卷 / 05期

关键词：

D O I：

10.1016/S1074-7613(04)00112-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The pathogenic roles of B cells in human autoimmune diseases involve a multitude of mechanistic pathways and include the well-established contributions of autoantibodies and immune complexes that induce local inflammatory reactions and tissue destruction. Recent results using several novel B cell-directed therapies have provided new insights into additional roles of B cells in human autoimmunity. In this review, we will highlight some of these studies and discuss how clinical insights parallel murine models of normal immunity and autoimmunity.

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收藏

页码：517 / 527

页数：11

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