Differential distribution of TASK-1, TASK-2 and TASK-3 immunoreactivities in the rat and human cerebellum

被引：32

作者：

Rusznák, Z ^{[1
]}

Pocsai, K ^{[1
]}

Kovács, I ^{[1
]}

Pór, A ^{[1
]}

Pál, B ^{[1
]}

Bíró, T ^{[1
]}

Szücs, G ^{[1
]}

机构：

[1] Univ Debrecen, Dept Physiol, Med Hlth Sci Ctr, H-4012 Debrecen, Hungary

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2004年 / 61卷 / 12期

关键词：

TASK immunopositivity; astrocyte culture; cerebellum; endoplasmic reticulum; human brain;

D O I：

10.1007/s00018-004-4082-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this work, the distributions of some acid-sensitive two-pore-domain K+ channels (TASK-1, TASK-2 and TASK-3) were investigated in the rat and human cerebellum. Astrocytes situated in rat cerebellar tissue sections were positive for TASK-2 channels. Purkinje cells were strongly stained and granule cells and astrocytes were moderately positive for TASK-3. Astrocytes isolated from the hippocampus, cerebellum and cochlear nucleus expressed TASK channels in a primary tissue culture. Our results suggest that TASK channel expression may be significant in the endoplasmic reticulum of the astrocytes. The human cerebellum showed weak TASK-2 immunolabelling. The pia mater, astrocytes, Purkinje and granule cells demonstrated strong TASK-1 and TASK-3 positivities. The TASK-3 labelling was stronger in general, but it was particularly intense in the Purkinje cells and pia mater.

引用

页码：1532 / 1542

页数：11

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