Use of a Baylis-Hillman adduct in the stereoselective synthesis of syributins via a RCM protocol

被引：57

作者：

Krishna, PR ^{[1
]}

Narsingam, M ^{[1
]}

Kannan, V ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Div Organ Chem 3, Discovery Lab, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 24期

关键词：

2,3-O-isopropylidene-R-glyceraldehyde; ethyl acrylate; Baylis-Hillman reaction; ring-closing metathesis; syributins;

D O I：

10.1016/j.tetlet.2004.04.080

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The total synthesis of syributins 1 and 2 using the Baylis-Hillman adduct of 2,3-O-isopropylidene-R-glyceraldehyde-ethyl acrylate as starting material followed by ring closing metathesis (RCM) of the acrylate derivative of the ensuing diol as the key step is reported. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：4773 / 4775

页数：3

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