Comprehensive multi-dimensional liquid chromatographic separation in biomedical and pharmaceutical analysis: a review

被引：84

作者：

Dixon, Steven P.

Pitfield, Ian D.

Perrett, David

机构：

[1] Bart & London Queen Marys Sch Med & Dent, John Vane Sci Ctr, London EC1M 6BQ, England

[2] GlaxoSmithKline, Analyt Sci, Tonbridge TN11 9AN, Kent, England

来源：

BIOMEDICAL CHROMATOGRAPHY | 2006年 / 20卷 / 6-7期

关键词：

metabolome; metabolomics; metabonomics; metabolite profiling; urine profiling;

D O I：

10.1002/bmc.672

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

'Multi-dimensional' liquid separations have a history almost as long as chromatography. In multi-dimensional chromatography the sample is subjected to more than one separation mechanism; each mechanism is considered an independent separation dimension. The separations can be carried out either offline via fraction collection, or directly coupled online. Early multi-dimensional separations using combinations of paper chromatography, electrophoresis and gels, in both planar and columnar modes are reviewed. Developments in HPLC have increased the number of measurable analytes in ever more complex matrices, and this has led to the concept of 'global metabolite profiling'. This review focuses on the theory and practice of modern 'comprehensive' multi-dimensional liquid chromatography when applied to biomedical and pharmaceutical analysis. Copyright (c) 2006 John Wiley & Sons, Ltd.

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页码：508 / 529

页数：22

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