Copper-Mediated Direct Arylation of 1,3,4-Oxadiazoles and 1,2,4-Triazoles with Aryl Iodides

被引：129

作者：

Kawano, Tsuyoshi ^{[1
]}

Yoshizumi, Tomoki ^{[1
]}

Hirano, Koji ^{[1
]}

Satoh, Tetsuya ^{[1
]}

Miura, Masahiro ^{[1
]}

机构：

[1] Osaka Univ, Dept Appl Chem, Fac Engn, Osaka 5650871, Japan

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 14期

关键词：

CATALYZED DIRECT ARYLATION; DIRECT C-2 ARYLATION; PALLADIUM; 1,2,3-TRIAZOLES; (HETERO)ARENES; HETEROARENES; HETEROCYCLES; DISCOVERY; INDOLES; DEVICES;

D O I：

10.1021/ol9011212

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The copper-mediated direct arylation of 1,3,4-oxadiazoles and 1,2,4-triazoles with aryl iodides proceeds efficiently in the presence of suitable ligands and bases. This method allows the installation of a variety of aryl moieties bearing a functional group such as ketone, ester, or nitrile so as to enable the facile construction of various functionalized oxadiazole and triazole core pi systems.

引用

页码：3072 / 3075

页数：4

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