The Neuropsychopharmacology of Fronto-Executive Function: Monoaminergic Modulation

被引：697

作者：

Robbins, T. W. ^{[1
,2
]}

Arnsten, A. F. T. ^{[3
]}

机构：

[1] Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England

[2] Univ Cambridge, Behav & Clin Neurosci Inst, Cambridge CB2 3EB, England

[3] Yale Univ, Sch Med, Dept Neurobiol, New Haven, CT 06510 USA

来源：

ANNUAL REVIEW OF NEUROSCIENCE | 2009年 / 32卷

基金：

英国医学研究理事会;

关键词：

prefrontal cortex; noradrenaline; dopamine; serotonin; attention; working memory; reinforcement learning; response inhibition; MEDIAL PREFRONTAL CORTEX; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; SPATIAL WORKING-MEMORY; COERULEUS-NORADRENERGIC SYSTEM; ACUTE TRYPTOPHAN DEPLETION; DELAYED-RESPONSE TASK; SET-SHIFTING ABILITY; EVENT-RELATED FMRI; LOCUS-COERULEUS; SEROTONIN DEPLETION;

D O I：

10.1146/annurev.neuro.051508.135535

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We review the modulatory effects of the catecholamine neurotransmitters noradrenaline and dopamine on prefrontal cortical function. The effects of pharmacologic manipulations of these systems, sometimes in comparison with the indoleamine serotonin (5-HT), on performance on a variety of tasks that tap working memory, attentional-set formation and shifting, reversal learning, and response inhibition are compared in rodents, nonhuman primates, and humans using, in a behavioral context, several techniques ranging from microiontophoresis and single-cell electrophysiological recording to pharmacologic functional magnetic resonance imaging. Dissociable effects of drugs and neuro-toxins affecting these monoamine systems suggest new ways of conceptualizing state-dependent fronto-executive functions, with implications for understanding the molecular genetic basis of mental illness and its treatment.

引用

页码：267 / 287

页数：21

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