Huntington's disease: New paths to pathogenesis

被引：47

作者：

Ross, CA

机构：

[1] Johns Hopkins Univ, Sch Med, Div Neurobiol, Dept Psychiat, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Div Neurobiol, Dept Neurol, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Div Neurobiol, Dept Neurosci, Baltimore, MD 21205 USA

来源：

CELL | 2004年 / 118卷 / 01期

关键词：

D O I：

10.1016/j.cell.2004.06.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Huntington's disease is a progressive autosomal dominant neurodegenerative disorder caused by expansion of a CAG repeat coding for polyglutamine in the huntingtin protein. A recent report (Gauthier et al., 2004, this issue of Cell) suggests a new mechanism involving altered interactions with a protein involved in axonal transport, leading to loss of neurotrophic factor transport. This suggests an intriguing convergence to previously described pathways implicating neurotrophin transcription in HD pathogenesis.

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页码：4 / 7

页数：4

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