A new series of selective dopamine D4 ligands: 3-([4-arylpiperazin-1-yl]alkylamino)-2H-1,4-benzoxazines

被引：5

作者：

He, XS

Woodruff, K

Brodbeck, R

机构：

[1] Department of Chemistry, Neurogen Corporation, Branford

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 18期

关键词：

D O I：

10.1016/S0960-894X(97)00442-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 3-[(4-arylpiperaz-1-yl)alkylamino]-2H-1,4-benzoxazines were prepared and their affinities for cloned human D-2, D-3, and D-4 dopamine receptor subtypes were measured. This led to the identification of 1a, 1f, and 1g as high affinity selective antagonists at the D-4 receptor. (C) 1997 Elsevier Science Ltd.

引用

页码：2399 / 2402

页数：4

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