Integrin-dependent neutrophil migration in extravascular tissue

被引:75
作者
Lindbom, L [1 ]
Werr, J [1 ]
机构
[1] Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden
关键词
chemotaxis; extracellular matrix; integrins; neutrophil migration;
D O I
10.1006/smim.2001.0348
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Leukocyte recruitment to sites of injury or infection involves sequential interactions with endothelium and extravascular tissue components. Mile the intravascular events in this process have been extensively studied, the mechanisms regulating subsequent passage through the surrounding tissue are less well characterized. The migrating while blood cells need to establish transient and dynamic adhesive contacts with extracellular matrix proteins. Integrin receptors expressed on the leukocyte surface play a central role in these interactions, mediating linkages between the cytoskeloton and the external environment. This chapter focuses on roles of integrin molecules in neutrophil locomotion and the adhesive mechanisms that govern the motility of these cells in the extravascular tissue.
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页码:115 / 121
页数:7
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