Staminolactones A and B and norstaminol A:: Three highly oxygenated staminane-type diterpenes from Orthosiphon stamineus

被引：26

作者：

Stampoulis, P

Tezuka, Y

Banskota, AH

Tran, KQ

Saiki, I

Kadota, S

机构：

[1] Toyama Med & Pharmaceut Univ, Inst Nat Med, Toyama 9300194, Japan

[2] Natl Univ Hochiminh City, Hochiminh, Vietnam

来源：

ORGANIC LETTERS | 1999年 / 1卷 / 09期

关键词：

D O I：

10.1021/ol990216+

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Staminolactones A (1) and B (2) and norstaminol A (3), three highly oxygenated staminane-type diterpenes having mild cytotoxic activities against highly liver metastatic colon 26-L5 carcinoma cells, were isolated from the aerial part of the Vietnamese medicinal plant Orthosiphon stamineus (Lamiaceae). Their structures were elucidated on the basis of the extensive spectral analyses.

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页码：1367 / 1370

页数：4

相关论文

共 15 条

[1] Cytotoxic cycloartane-type triterpenes from Combretum quadrangulare [J].

Banskota, AH ;

Tezuka, Y ;

Phung, LK ;

Tran, KQ ;

Saiki, I ;

Miwa, Y ;

Taga, T ;

Kadota, S .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1998, 8 (24) :3519-3524

[2] Chemical constituents of Brazilian propolis and their cytotoxic activities [J].

Banskota, AH ;

Tezuka, Y ;

Prasain, JK ;

Matsushige, K ;

Saiki, I ;

Kadota, S .

JOURNAL OF NATURAL PRODUCTS, 1998, 61 (07) :896-900

[3] BRASSINOLIDE, A PLANT GROWTH-PROMOTING STEROID ISOLATED FROM BRASSICA-NAPUS POLLEN [J].

GROVE, MD ;

SPENCER, GF ;

ROHWEDDER, WK ;

MANDAVA, N ;

WORLEY, JF ;

WARTHEN, JD ;

STEFFENS, GL ;

FLIPPENANDERSON, JL ;

COOK, JC .

NATURE, 1979, 281 (5728) :216-217

[4] MYCOLIC ACID METABOLIC FILIATION AND LOCATION IN MYCOBACTERIUM-AURUM AND MYCOBACTERIUM-PHLEI [J].

LACAVE, C ;

LANEELLE, MA ;

DAFFE, M ;

MONTROZIER, H ;

LANEELLE, G .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1989, 181 (02) :459-466

[5] FURTHER-STUDIES ON THE BIOSYNTHESIS OF CHLOROTHRICIN [J].

LEE, JJ ;

LEE, JP ;

KELLER, PJ ;

COTTRELL, CE ;

CHANG, CJ ;

ZAHNER, H ;

FLOSS, HG .

JOURNAL OF ANTIBIOTICS, 1986, 39 (08) :1123-1134

[6] ORTHOSIPHOL-A, A HIGHLY OXYGENATED DITERPENE FROM THE LEAVES OF ORTHOSIPHON-STAMINEUS [J].

MASUDA, T ;

MASUDA, K ;

NAKATANI, N .

TETRAHEDRON LETTERS, 1992, 33 (07) :945-946

[7] ORTHOSIPHOL-A AND ORTHOSIPHOL-B, NOVEL DITERPENOID INHIBITORS OF TPA (12-O-TETRADECANOYLPHORBOL-13-ACETATE)-INDUCED INFLAMMATION, FROM ORTHOSIPHON-STAMINEUS [J].

MASUDA, T ;

MASUDA, K ;

SHIRAGAMI, S ;

JITOE, A ;

NAKATANI, N .

TETRAHEDRON, 1992, 48 (33) :6787-6792

[8] Characterization of a liver metastatic variant of murine colon 26 carcinoma cells [J].

Ohnishi, Y ;

Sakamoto, T ;

Fujii, H ;

Kimura, F ;

Murata, J ;

Tazawa, K ;

Fujimaki, M ;

Sato, Y ;

Kondo, M ;

Une, Y ;

Uchino, J ;

Saiki, I .

TUMOR BIOLOGY, 1997, 18 (02) :113-122

[9] Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin [J].

Prado, L ;

Fernández, E ;

Weissbach, U ;

Blanco, G ;

Quirós, LM ;

Braña, AF ;

Méndez, C ;

Rohr, J ;

Salas, JA .

CHEMISTRY & BIOLOGY, 1999, 6 (01) :19-30

[10]

Shibuya H, 1999, CHEM PHARM BULL, V47, P911