Palladium/P(t-Bu)3-catalyzed synthesis of aryl t-butyl ethers and application to the first synthesis of 4-chlorobenzofuran

被引：71

作者：

Watanabe, M ^{[1
]}

Nishiyama, M ^{[1
]}

Koie, Y ^{[1
]}

机构：

[1] Tosoh Corp, Yokkaichi Res Lab, Yokkaichi, Mie 5108540, Japan

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 50期

关键词：

alkoxylation; aryl halides; benzofurans; ethers; palladium catalysts;

D O I：

10.1016/S0040-4039(99)01855-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pd/P(t-Bu)(3) catalyzed reaction of aryl halides with sodium t-butoxide effectively to give aryl t-butyl ethers. The high catalytic activity realized the formation of aryl t-butyl ethers from not only electron-deficient aryl halides but also electron-rich aryl halides. Moreover, the first synthesis of 4-chlorobenzofuran was attained utilizing the selective mono-t-butoxylation of aryl dihalide. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：8837 / 8840

页数：4

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