Synthesis of N-arylpiperazines from aryl halides and piperazine under a palladium tri-tert-butylphosphine catalyst

被引：351

作者：

Nishiyama, M ^{[1
]}

Yamamoto, T ^{[1
]}

Koie, Y ^{[1
]}

机构：

[1] Tosoh Co Ltd, Yokkaichi Res Lab, Yokkaichi, Mie 510, Japan

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 07期

关键词：

D O I：

10.1016/S0040-4039(97)10659-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Pd/P(t-Bu)(3) catalyst system has revealed very high activity and selectivity for the amination of N-(hetero)aryl halides with unprotected piperazine. A wide variety of N-(hetero)arylpiperazines could be prepared using this catalyst. Turnover numbers up to 6400mol/mol have been obtained. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：617 / 620

页数：4

共 12 条

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