Regulation of C-terminal and intact FGF-23 by dietary phosphate in men and women

被引：358

作者：

Burnett, Sherri-Ann M.

Gunawardene, Samantha C.

Bringhurst, F. Richard

Juppner, Harald

Lee, Hang

Finkelstein, Joel S.

机构：

[1] Massachusetts Gen Hosp, Endocrine Unit, Boston, MA 02114 USA

[2] Massachusetts Gen Hosp, Ctr Biostat, Boston, MA 02114 USA

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2006年 / 21卷 / 08期

关键词：

fibroblast growth factor 23; phosphate; homeostasis; nutrition;

D O I：

10.1359/JBMR.060507

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

FGF-23 is a novel regulator of phosphate metabolism. We studied the regulation of FGF-23 by dietary phosphate in 66 men and women using two assays. Dietary phosphate restriction decreased FGF-23 and loading increased FGF-23 significantly. An assay that measured intact FGF-23 showed the effects of dietary phosphate much more clearly than an assay that also measures presumed biologically inactive fragments. Dietary phosphate is a key regulator of circulating FGF-23; choice of assay is critical when studying FGF-23 physiology.

引用

收藏

页码：1187 / 1196

页数：10

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