The genetics of axonal transport and axonal transport disorders

被引：105

作者：

Duncan, Jason E. ^{[1
]}

Goldstein, Lawrence S. B. ^{[1
]}

机构：

[1] Univ Calif San Diego, Howard Hughes Med Inst, Dept Cellular & Mol Med, Sch Med, La Jolla, CA 92093 USA

来源：

PLOS GENETICS | 2006年 / 2卷 / 09期

关键词：

D O I：

10.1371/journal.pgen.0020124

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Neurons are specialized cells with a complex architecture that includes elaborate dendritic branches and a long, narrow axon that extends from the cell body to the synaptic terminal. The organized transport of essential biological materials throughout the neuron is required to support its growth, function, and viability. In this review, we focus on insights that have emerged from the genetic analysis of long-distance axonal transport between the cell body and the synaptic terminal. We also discuss recent genetic evidence that supports the hypothesis that disruptions in axonal transport may cause or dramatically contribute to neurodegenerative diseases.

引用

页码：1275 / 1284

页数：10

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