Alkaloids from South African Amaryllidaceae -: Part 7 -: Bioactive alkaloids from Brunsvigia radulosa

被引：64

作者：

Campbell, WE ^{[1
]}

Nair, JJ

Gammon, DW

Codina, C

Bastida, J

Viladomat, F

Smith, PJ

Albrecht, CF

机构：

[1] Univ Cape Town, Dept Chem, ZA-7700 Rondebosch, South Africa

[2] Univ Barcelona, Fac Farm, Dept Nat Prod, E-08028 Barcelona, Spain

[3] Univ Cape Town, Dept Pharmacol, ZA-7925 Observatory, South Africa

[4] Univ Stellenbosch, Dept Pharmacol, ZA-7505 Tygerberg, South Africa

来源：

PHYTOCHEMISTRY | 2000年 / 53卷 / 05期

关键词：

Amaryllidaceae; Brunsvigia radulosa; alkaloids; 1-O-acetylnorpluviine; apohaemanthamine; 1-epideacetylbowdensine; crinamine; crinine; hamayne; lycorine; anhydrolycorin-6-one; sternbergine;

D O I：

10.1016/S0031-9422(99)00575-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

A phytochemical investigation of the bulbs of Brunsvigia radulosa yielded the new alkaloid 1-O-acetylnorpluviine, together with the known structures 1-epideacetylbowdensine, crinamine, crinine, hamayne, lycorine, anhydrolycorin-6-one and sternbergine. All structures were established by spectroscopic evidence. Some of the: C-13 assignments which were reported for crinamine and hamayne were corrected by means of 2D NMR techniques. Tn order to provide a further structure for biological testing, crinamine was converted to apohaemanthamine. The alkaloids were tested for activity against two strains of cultured Plasmodium falciparum and for cytotoxicity with BL6 mouse melanoma cells. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：587 / 591

页数：5

共 13 条

[1]

Composition and antimalarial activity in vitro of the essential oil of Tetradenia riparia [J].