Interleukin-6 release from the human brain during prolonged exercise

被引:143
作者
Nybo, L
Nielsen, B
Pedersen, BK
Moller, K
Secher, NH
机构
[1] Univ Copenhagen, August Krogh Inst, Inst Exercise & Sport Sci, Dept Human Physiol, DK-2100 Copenhagen O, Denmark
[2] Univ Copenhagen, Rigshosp, Copenhagen Muscle Res Ctr, Dept Infect Dis, DK-2100 Copenhagen O, Denmark
[3] Univ Copenhagen, Rigshosp, Copenhagen Muscle Res Ctr, Dept Anaesthesia, DK-2100 Copenhagen O, Denmark
来源
JOURNAL OF PHYSIOLOGY-LONDON | 2002年 / 542卷 / 03期
关键词
D O I
10.1113/jphysiol.2002.022285
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Interleukin (IL)-6 is a pleiotropic cytokine, which has a variety of physiological roles including functions within the central nervous system. Circulating IL-6 increases markedly during exercise, partly due to the release of IL-6 from the contracting skeletal muscles, and exercise-induced IL-6 may be linked with central fatigue, which is enhanced by hyperthermia. Exercise-induced IL-6 may also stimulate hepatic glycogenolysis, which is important during prolonged and repeated exercise. Thus, in a randomised order and separated by 60 min of rest, eight young mate subjects completed two 60 min exercise bouts: one bout with a normal (38 degreesC) and the other with an elevated (39.5 degreesC) core temperature. The cerebral IL-6 response was determined on the basis of internal jugular venous to arterial IL-6 differences and global cerebral blood flow. There was no net release or uptake of IL-6 in the brain at rest or after 15 min of exercise, but a small release of IL-6 was observed after 60 min of exercise in the first bout (0.06 +/- 0.03 ng min(-1)). This release of IL-6 from the brain was five-fold greater at the end of the second bout (0.30 +/- 0.08 ng min(-1); P < 0.05) with no separate influence of hyperthermia. In conclusion, IL-6 is released from the brain during prolonged exercise in humans and it appears that the duration of the exercise rather than the increase in body temperature dictates the cerebral IL-6 response.
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收藏
页码:991 / 995
页数:5
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