Formation of thymine clusters in genomes of higher eukaryotes

被引：1

作者：

Amano, N

Suzuki, M

机构：

[1] Natl Inst Adv Ind Sci & Technol, AIST Tsukuba Ctr 6 10, Tsukuba, Ibaraki 3058566, Japan

[2] Univ Tsukuba, Doctoral Program Med Sci, Tsukuba, Ibaraki 3050006, Japan

来源：

PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES | 2002年 / 78卷 / 06期

关键词：

Arabidopsis thaliana; Caenorhabiditis elegans; chromatin structure; chromosome formation; DNA structure; human genome;

D O I：

10.2183/pjab.78.161

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In genomes of higher eukaryotes, the numbers of clusters of 10 or more thymine nucleotides are much larger than what are expected for radom combinations. The T bases in clusters occupy increasing percentages of the genomes with increasing the genome size, reaching 0.7% in human. The frequencies of these clusters in introns and intergenic regions are higher than that in exons, although the average lengths of clusters are similar in the three regions. Possible functions of T clusters for stabilizing chromatin and chromosome structures are discussed.

引用

页码：161 / 166

页数：6

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