A genome screen for linkage disequilibrium in HLA-DRB1*15-positive Germans with multiple sclerosis based on 4666 microsatellite markers

被引：31

作者：

Goedde, R

Sawcer, S

Boehringer, S

Miterski, B

Sindern, E

Haupts, M

Schimrigk, S

Compston, A

Epplen, JT

机构：

[1] Ruhr Univ Bochum, Dept Mol Human Genet, D-44780 Bochum, Germany

[2] Ruhr Univ Bochum, Kliniken Bergmannsheil, Dept Neurol, Bochum, Germany

[3] Ruhr Univ Bochum, Dept Neurol, Knappschaftskrankenhaus, Bochum, Germany

[4] Ruhr Univ Bochum, St Josef Hosp, Dept Neurol, Bochum, Germany

[5] Univ Cambridge, Neurol Unit, Addenbrookes Hosp, Cambridge CB2 2QQ, England

来源：

HUMAN GENETICS | 2002年 / 111卷 / 03期

基金：

英国惠康基金;

关键词：

D O I：

10.1007/s00439-002-0801-8

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Multiple sclerosis (MS) is a demyelinating disorder of the central nervous system with putative autoimmune aetiology and complex genetic background. Here, we report the results of a genome screen for linkage disequilibrium (LD) by using 6000 microsatellite markers in 198 HLA-DRB1*15-positive MS patients and 198 unrelated controls (pooled DNA); 4666 analysed markers could be included in the resulting association map, from which 87 revealed significant differences between MS cases and controls.

引用

页码：270 / 277

页数：8

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