Early molecular events in PAMP-triggered immunity

被引:374
作者
Zipfel, Cyril [1 ]
机构
[1] Sainsbury Lab, Norwich NR4 7UH, Norfolk, England
基金
英国生物技术与生命科学研究理事会;
关键词
RECEPTOR-KINASE; INNATE IMMUNITY; PSEUDOMONAS-SYRINGAE; DISEASE RESISTANCE; FLAGELLIN PERCEPTION; ARABIDOPSIS; DEFENSE; EFFECTOR; EVOLUTION; ELICITOR;
D O I
10.1016/j.pbi.2009.06.003
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
In plant innate immunity, the first line of microbial recognition leading to active defence responses relies on the perception of pathogen-associated molecular patterns (PAMPs) by pattern-recognition receptors (PRRs). This recognition leads to PAMP-triggered immunity (PTI). Despite the numerous PAMPs recognised by plants, only a handful of PRRs are characterised. For most, they correspond to transmembrane proteins with a ligand-binding ectodomain. PRRs interact with additional transmembrane proteins that act as signalling adapters or amplifiers to achieve full functionality. The crucial role of PRRs in anti-microbial immunity is demonstrated by the direct targeting of PRRs and their associated proteins by pathogenic virulence effectors.
引用
收藏
页码:414 / 420
页数:7
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