The stereocontrolled synthesis of enantiopure alpha-methano heterocycles and constrained amino acid analogs

被引：27

作者：

Hanessian, S

Reinhold, U

Ninkovic, S

机构：

[1] Department of Chemistry, Université de Montréal, Montréal, Que. H3C 3J7, P.O.Box 6128, Station Centre-ville

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 50期

关键词：

D O I：

10.1016/S0040-4039(96)02104-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Addition of trimethylstannyl radicals to acrylate and acrylamide derivatives that contain olefinic groups leads to the corresponding lactones and lactams with good to excellent stereochemical control. alpha-Methane heterocycles can be easily elaborated from the alpha-trimethylstannylmethyl intermediates via putative oxonium and iminium ions generated under acids conditions. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：8967 / 8970

页数：4

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