Synthesis of oxygenated spongiane-type diterpenoids from carvone

被引：8

作者：

Abad, A ^{[1
]}

Agulló, C ^{[1
]}

Cuñat, AC ^{[1
]}

García, AB ^{[1
]}

机构：

[1] Univ Valencia, Dept Quim Organ, E-46100 Valencia, Spain

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 44期

关键词：

D O I：

10.1016/S0040-4039(02)01891-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new diastereo selective approach to oxygenated spongiane diterpenes starting from (R)-(-)-carvone is described. The carvone is incorporated as the B ring in the final spongiane framework using a B -->AB-->ABC-->ABCD approach, which involves an intramolecular Diels-Alder reaction and the regioselective ring-opening of a dihydrofuran ring as key synthetic steps. The structure of the key intermediate in this approach has been verified by X-ray crystallography. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：7933 / 7936

页数：4

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