Weak mutators can drive the evolution of fluoroquinolone resistance in Escherichia coli

被引：26

作者：

Orlen, Hanna ^{[1
]}

Hughes, Diarmaid ^{[1
]}

机构：

[1] Uppsala Univ, Biomed Ctr, Dept Cell & Mol Biol, S-75124 Uppsala, Sweden

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 10期

关键词：

D O I：

10.1128/AAC.00783-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Weak mutators are common among clinical isolates of Escherichia coli. We show that the relative mutation rate and the "evolvability of fluoroquinolone resistance" are related by a power law slope of 1.2 over 3 orders of magnitude. Thus, even weak mutators can drive the evolution of fluoroquinolone resistance under selection pressure.

引用

页码：3454 / 3456

页数：3

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