Not so Fas: Re-evaluating the mechanisms of immune privilege and tumor escape

被引：206

作者：

Restifo, NP ^{[1
]}

机构：

[1] NCI, NIH, Bethesda, MD 20892 USA

来源：

NATURE MEDICINE | 2000年 / 6卷 / 05期

关键词：

D O I：

10.1038/74955

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Based on early studies, it was hypothesized that expression of Fas ligand (FasL) by tumor cells enabled them to counterattack the immune system, and that transplant rejection could be prevented by expressing FasL on transplanted organs. More recent studies have indicated that the notion of FasL as a mediator of immune privilege needed to be reconsidered, and taught a valuable lesson about making broad conclusions based on small amounts of data.

引用

页码：493 / 495

页数：3

共 31 条

[21] FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex
Muzio, M
Chinnaiyan, AM
Kischkel, FC
ORourke, K
Shevchenko, A
Ni, J
Scaffidi, C
Bretz, JD
Zhang, M
Gentz, R
Mann, M
Krammer, PH
Peter, ME
Dixit, VM
[J]. CELL, 1996, 85 (06) : 817 - 827
[22] Fas counter-attack - the best form of tumor defense?
O'Connell, J
Bennett, MW
O'Sullivan, GC
Collins, JK
Shanahan, F
[J]. NATURE MEDICINE, 1999, 5 (03) : 267 - 268
[23] VIRAL INHIBITION OF INFLAMMATION - COWPOX VIRUS ENCODES AN INHIBITOR OF THE INTERLEUKIN-1-BETA CONVERTING ENZYME
RAY, CA
BLACK, RA
KRONHEIM, SR
GREENSTREET, TA
SLEATH, PR
SALVESEN, GS
PICKUP, DJ
[J]. CELL, 1992, 69 (04) : 597 - 604
[24] Seino K, 1998, J IMMUNOL, V161, P4484
[25] Rejection of Fas ligand-expressing grafts
Seino, K
Kayagaki, N
Fukao, K
Okumura, K
Yagita, H
[J]. TRANSPLANTATION PROCEEDINGS, 1997, 29 (1-2) : 1092 - 1093
[26] Contribution of Fas ligand to cardiac allograft rejection
Seino, K
Kayagaki, N
Bashuda, H
Okumura, K
Yagita, H
[J]. INTERNATIONAL IMMUNOLOGY, 1996, 8 (09) : 1347 - 1354
[27] SELNO K, 1999, TRANSPLANT P, V31, P1942
[28] Smith D, 1998, J IMMUNOL, V160, P4159
[29] Vaux DL, 1998, NATURE, V394, P133, DOI 10.1038/28067
[30] Yagita H, 1996, NATURE, V379, P682, DOI 10.1038/379682a0

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