Mastering the complexity of DNA nanostructures

被引:21
作者
Brucale, Marco
Zuccheri, Giampaolo
Samori, Bruno
机构
[1] Univ Bologna, Dept Biochem G Moruzzi, I-40126 Bologna, Italy
[2] CNR, INFM, Natl Ctr Nanostruct & Biosyst Surfaces, I-41100 Modena, Italy
关键词
D O I
10.1016/j.tibtech.2006.02.009
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The self-assembly of oligodeoxynucleotides is a versatile and powerful tool for the construction of objects in the nanoscale. The strictly information-driven pairing of DNA fragments can be used to rationally design and build nanostructures with planned topologies and geometries. Taking advantage of the steadily expanding library of well-characterized DNA motifs, several examples of structures with different dimensionalities have appeared in the literature in the past few years, laying the foundations for a promising DNA-mediated, bottom-up approach to nanotechnology. This article focuses on recent developments in this area of research and proposes a classification of DNA nanostructures based on topological considerations in addition to describing strategies for tackling the inherent complexities of such an endeavor.
引用
收藏
页码:235 / 243
页数:9
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