Microfluidic-Based Generation of Size-Controlled, Biofunctionalized Synthetic Polymer Microgels for Cell Encapsulation

被引：192

作者：

Headen, Devon M. ^{[1
,2
]}

Aubry, Guillaume ^{[3
]}

Lu, Hang ^{[2
,3
]}

Garcia, Andres J. ^{[1
,2
]}

机构：

[1] Georgia Inst Technol, George W Woodruff Sch Mech Engn, Atlanta, GA 30332 USA

[2] Petit Inst Bioengn & Biosci, Atlanta, GA 30332 USA

[3] Sch Chem & Biomol Engn, Atlanta, GA 30332 USA

来源：

ADVANCED MATERIALS | 2014年 / 26卷 / 19期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

microfluidics; cell microencapsulation; synthetic microgel; pancreatic islets; hydrogels; DESIGNING MATERIALS; HYDROGEL; MONODISPERSE; ISLETS; MICROFIBERS; MICROBEADS;

D O I：

10.1002/adma.201304880

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Cell and islet microencapsulation in synthetic hydrogels provides an immunoprotective and cell-supportive microenvironment. A microfluidic strategy for the genaration of biofunctionalized, synthetic microgel particles with precise control over particle size and molecular permeability for cell and protein delivery is presented. These engineered capsules support high cell viability and function of encapsulated human stem cells and islets. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：3003 / 3008

页数：6

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